Category: Science

Notes from “How Not to Age” Part 2 — Presentation by Dr. Michael Greger

This is the second section of my notes on Dr. Greger’s presentation. It covers three topics: Habits of longest-living populations and Healthy vs. unhealthy plant-based diets . If there are errors in this post, they are likely mine, let me know and I will correct it

One of the most important takeaways for me from these segments was the importance of eating a healthy plant-based diet. If you eat ultra-processed vegan foods, you’re likely not improving your health! I know this but the data Dr. Greger brings to bear helps reinforce the need for healthy whole food, plant-based diet instead unhealthy but convenient, hyper-palatable, ultra processed food.

[21:25] Habits of longest-living populations

  • (from How Not to Age Part II: Optimal Anti-Aging Regimen)
    • Odds of living to 100 have increased to 1 in 50 for women in low-mortality areas
    • Twin studies suggest only 25% of lifespan variation explained by genetics
    • Blue Zones – areas of exceptional longevity around the world [27]
    • Five Blue Zones identified around the world
      • Loma Linda, CA, USA, Sardinia, Greece, Okinawa, Costa Rica
Blue Zone Food Guidelines
Blue Zone Food Guidelines [27]
  • Common Blue Zone lifestyle characteristics [29]
    • family coherence, 
    • avoidance of smoking, 
    • plant-based diet, 
    • moderate and daily physical activity, 
    • social engagement, where people of all ages are socially active and integrated into the community
Plant based diet accounts for half of difference in Blue Zone lifespan
Plant based diet accounts for half of the difference in Blue Zone lifespan [30]
  • Number 1 risk factor is American diet
  • A sustained change from a typical Western diet to the optimal diet from age 20 years would increase LE by more than a decade for women from the United States (10.7 [95% UI 8.4 to 12.3] years) and men (13.0 [95% UI 9.4 to 14.3] years). [31]
    • The largest gains would be made by eating more legumes (females: 2.2 [95% UI 1.1 to 3.4]; males: 2.5 [95% UI 1.1 to 3.9]),
    • [more] whole grains (females: 2.0 [95% UI 1.3 to 2.7]; males: 2.3 [95% UI 1.6 to 3.0]), and 
    • [more] nuts (females: 1.7 [95% UI 1.5 to 2.0]; males: 2.0 [95% UI 1.7 to 2.3]), and 
    • less red meat (females: 1.6 [95% UI 1.5 to 1.8]; males: 1.9 [95% UI 1.7 to 2.1]) and 
    • [less] processed meat (females: 1.6 [95% UI 1.5 to 1.8]; males: 1.9 [95% UI 1.7 to 2.1]). 
    • Changing from a typical diet to the optimized diet at age 60 years would increase LE by 8.0 (95% UI 6.2 to 9.3) years for women and 8.8 (95% UI 6.8 to 10.0) years for men, and
      • 80-year-olds would gain 3.4 years (95% UI females: 2.6 to 3.8/ males: 2.7 to 3.9)
Replacing just 3% of animal protein with plant protein can improve life expectancy 10%
Replacing just 3% of animal protein with plant protein can improve life expectancy 10% [32]
  • Does eating healthy actually slow down aging?[33]
    • “Women who participated in the dietary intervention had a significant slowing of the DNAmGrimAge clock” [34]
  • “It’s not just about adding years to your life but life to your years.”
    • Unhealthy Aging Measure called Deficit Accumulation Index (DAI)
      • Deficit Accumulation Index. At each wave, unhealthy aging was measured using a 52-item DAI with 4 domains: functional impairments, self-reported health/vitality, mental health, and morbidities/use of health services.
        “…. substitution of 1% of energy from vegetable protein for an equal amount of total animal protein, dairy protein, or meat protein also led to significantly less deficit accumulation.” ” [35] 
    • “Substituting 5% energy of animal protein with plant protein was associated with a lower risk of all‐cause mortality (HR, 0.86; 95% CI, 0.81–0.91), CVD mortality (HR, 0.78, 95% CI, 0.70–0.87), and dementia mortality (HR, 0.81, 95% CI, 0.68–0.97” [36]
  • Those who eat no meat at all are three times less likely to become demented
    “The matched subjects who ate meat (including poultry and fish) were more than twice as likely to become demented as their vegetarian counterparts (relative risk 2.18, p = 0.065) and the discrepancy was further widened (relative risk 2.99, p = 0.048) when past meat consumption was taken into account. “ [37]
Sodium is the worst thing in our diet
Sodium is the worst thing in our diet [38], Switching to half sodium/half potassium can increase life expectancy

30:55 Healthy vs. unhealthy plant-based diets

  • Ultra-processed foods
    • “…. in high income and, increasingly, in middle-income countries, ultra-processed foods consistently account for more than 50% of dietary energy.”,[39]
    • Ultra-processed foods associated with increase risk of dying prematurely
    • Unhealthy plant-based diets are not associated with a lower risk of dying[40]
Unhealthy plant based diets (uPDI) increase overall risk of death even if animal product consumption is low
Unhealthy plant based diets (uPDI) increase overall risk of death even if animal product consumption is low [41]
Unhealthy plant foods (uPDI) increases risk of death
The Million Veteran study:
Healthy plant foods (hPDI) decreases risk of death
Unhealthy plant foods (uPDI) increases risk of death [42]
Only healthy plant foods reduce risk of cognitive impairment
Only healthy plant foods reduce the risk of cognitive impairment [43]
  • Dr. Greger presented similar data for dementia and depression, frailty
  • “In order to distinguish between healthful and unhealthful vegan diets that majorly include refined and processed foods, the term whole food, plant-based diet was developed by Dr. T. Colin Campbell in the early 1980s. The current definition of a plant-based diet is one that consists of all minimally processed fruits, vegetables, whole grains, legumes, nuts, seeds, herbs, and spices and excludes all animal products, including red meat, fish, poultry, eggs, and dairy products.”[44]
  • Vegans can still benefit from whole food, plant-based diet [45]

References

  • [27] A great book to read is Buettner D. The Blue Zones: 9 Lessons for Living Longer from the People Who’ve Lived the Longest. 2nd ed. National Geographic Books; 2012. Cited as 1486 and 2403 in How Not to Age Citations.
    Dan Buettner has done much research on Blue Zones and has written other books. He also has a recent 2023 series on Netflix, Live to 100: Secrets of the Blue Zones
    [28] Food guidelines. BlueZones.com. https://www.bluezones.com/recipes/food-guidelines/. Accessed 2 December 2023 Cited as 2393 and 2396 in How Not to Age Citations
  • [29] Panagiotakos DB, Chrysohoou C, Siasos G, Zisimos K, Skoumas J, Pitsavos C, Stefanadis C. Sociodemographic and lifestyle statistics of oldest old people (>80 years) living in ikaria island: the ikaria study. Cardiol Res Pract. 2011 Feb 24;2011:679187. doi: 10.4061/2011/679187. PMID: 21403883; PMCID: PMC3051199. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051199/
    Cited as 2392 in How Not to Age Citations
  • [30] Kahleova H, Levin S, Barnard ND. Plant-Based Diets for Healthy Aging. J Am Coll Nutr. 2021 Jul;40(5):478-479. doi: 10.1080/07315724.2020.1790442. Epub 2020 Jul 9. PMID: 32643581. Behind a paywall Available at https://www.researchgate.net/publication/342818806_Plant-Based_Diets_for_Healthy_Aging
    Cited as 2147, 2150 and 2742 in How Not to Age Citations
  • [31] Fadnes LT, Økland JM, Haaland ØA, Johansson KA. Estimating impact of food choices on life expectancy: A modeling study. PLoS Med. 2022 Feb 8;19(2):e1003889. doi: 10.1371/journal.pmed.1003889. Erratum in: PLoS Med. 2022 Mar 25;19(3):e1003962. PMID: 35134067; PMCID: PMC8824353. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824353/
    Cited as 2216, 2406 and 2436 in How Not to Age Citations
  • [32] Song M, Fung TT, Hu FB, Willett WC, Longo VD, Chan AT, Giovannucci EL. Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Intern Med. 2016 Oct 1;176(10):1453-1463. doi: 10.1001/jamainternmed.2016.4182. Erratum in: JAMA Intern Med. 2016 Nov 1;176(11):1728. PMID: 27479196; PMCID: PMC5048552. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048552/
    Cited as 3747, 3750 and 3752 in How Not to Age Citations
  • [33] Fiorito G, Caini S, Palli D, Bendinelli B, Saieva C, Ermini I, Valentini V, Assedi M, Rizzolo P, Ambrogetti D, Ottini L, Masala G. DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study. Aging Cell. 2021 Oct;20(10):e13439. doi: 10.1111/acel.13439. Epub 2021 Sep 18. PMID: 34535961; PMCID: PMC8520727. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520727/
    Not cited in How Not to Age Citations
  • [34] DNAmGrimAge clock, whereas increasing physical activity led to a significant reduction of SEMs in crucial cancer‐related pathways.” Since the article states: “stochastic epigenetic mutations (SEMs), also known as the epigenetic mutation load (EML), has been proposed as a complementary DNAm‐based biomarker of healthy aging.” then a reduction in SEMs would be beneficial. In other words, increased physical activity does “reduce” aging which is contrary to what Dr. Greger said
  • [35] Ortolá R, Struijk EA, García-Esquinas E, Rodríguez-Artalejo F, Lopez-Garcia E. Changes in Dietary Intake of Animal and Vegetable Protein and Unhealthy Aging. Am J Med. 2020 Feb;133(2):231-239.e7. doi: 10.1016/j.amjmed.2019.06.051. Epub 2019 Jul 29. PMID: 31369726. Behind paywall but found at https://www.fisiogenomica.com/assets/Blog/pdf/Prote%C3%ADnas%2010.1016@j.amjmed.2019.06.051.pdf
    Cited as 2762, 2763, 5535, 5664, and 7902 in How Not to Age Citations but the link is to the wrong paper
  • [36] Sun Y, Liu B, Snetselaar LG, Wallace RB, Shadyab AH, Kroenke CH, Haring B, Howard BV, Shikany JM, Valdiviezo C, Bao W. Association of Major Dietary Protein Sources With All-Cause and Cause-Specific Mortality: Prospective Cohort Study. J Am Heart Assoc. 2021 Feb;10(5):e015553. doi: 10.1161/JAHA.119.015553. Epub 2021 Feb 24. PMID: 33624505; PMCID: PMC8174240. https://www.ahajournals.org/doi/10.1161/JAHA.119.015553
    Cited as references 951, 3752, 6763 and 7903 in in How Not to Age Citations
  • [37] Giem P, Beeson WL, Fraser GE. The incidence of dementia and intake of animal products: preliminary findings from the Adventist Health Study. Neuroepidemiology. 1993;12(1):28-36. doi: 10.1159/000110296. PMID: 8327020. Behind paywall
    Cited as references 51, 744, 2747. 5048 and 5532 in in How Not to Age Citations
  • [38]
  • GBD 2017 Diet Collaborators. Health effects of dietary risks in 195 countries, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2019 May 11;393(10184):1958-1972. doi: 10.1016/S0140-6736(19)30041-8. Epub 2019 Apr 4. Erratum in: Lancet. 2021 Jun 26;397(10293):2466. PMID: 30954305; PMCID: PMC6899507. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899507/
    Cited as references 1261, 2104, 2115, and 2163 in in How Not to Age Citations
  • [39] Adams J, Hofman K, Moubarac JC, Thow AM. Public health response to ultra-processed food and drinks. BMJ. 2020 Jun 26;369:m2391. doi: 10.1136/bmj.m2391. PMID: 32591348; PMCID: PMC7318879.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318879/ Not referenced in How Not to Age Citations
    • Definition of Ultra-processed food and drink products  -Formulations of ingredients, mostly of exclusive industrial use, that result from a series of industrial processes, many requiring sophisticated equipment and technology. These include the fractioning of whole foods into substances, chemical modifications of these substances, assembly of unmodified and modified food substances using industrial techniques such as extrusion, moulding and pre-frying, frequent application of additives whose function is to make the final product palatable or hyper-palatable (cosmetic additives), and sophisticated packaging, usually with synthetic materials
    • Examples of Ultra-processed food and drink products  – Carbonated drinks; ice cream, chocolate, confectionery; mass produced packaged breads and buns; margarines and spreads; biscuits, pastries, cakes, and cake mixes; breakfast cereals, cereal and energy bars; energy drinks; milk drinks, fruit yoghurts, and fruit drinks; meat and chicken extracts and instant sauces; infant formula milks and other baby products; health and slimming products such as meal substitutes; many ready to heat products, including pies, pasta dishes, and pizza; poultry and fish nuggets, sausages, burgers, and hot dogs; and instant soups, noodles, and desserts
  • [40] Kim H, Caulfield LE, Rebholz CM. Healthy Plant-Based Diets Are Associated with Lower Risk of All-Cause Mortality in US Adults. J Nutr. 2018 Apr 1;148(4):624-631. doi: 10.1093/jn/nxy019. PMID: 29659968; PMCID: PMC6669955. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669955/
    Cited as references 2145, and 2791 in in How Not to Age Citations
    • The referenced paper is much more equivocal: “We did not observe significant results for the healthy plant-based diets and cardiovascular disease mortality in the overall study population, or in sex-specific strata.”
  • [41] Baden MY, Liu G, Satija A, Li Y, Sun Q, Fung TT, Rimm EB, Willett WC, Hu FB, Bhupathiraju SN. Changes in Plant-Based Diet Quality and Total and Cause-Specific Mortality. Circulation. 2019 Sep 17;140(12):979-991. doi: 10.1161/CIRCULATIONAHA.119.041014. Epub 2019 Aug 12. PMID: 31401846; PMCID: PMC6746589. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746589/
    Cited as references 2800 in in How Not to Age Citations
  • [42] Wang, D., Li, Y., Nguyen, X., Song, R., Ho, Y., Hu, F., . . . Djoussé, L. (2023). Degree of adherence to plant-based diet and total and cause-specific mortality: Prospective cohort study in the Million Veteran Program. Public Health Nutrition, 26(2), 381-392. doi:10.1017/S1368980022000659 https://www.cambridge.org/core/journals/public-health-nutrition/article/degree-of-adherence-to-plantbased-diet-and-total-and-causespecific-mortality-prospective-cohort-study-in-the-million-veteran-program/91A237B3950086867063974662ED82C8
    not referenced in How Not to Age citations, it’s a recent 2023 paper.
  • [43] Ding K, Zeng J, Zhang X, Wang Y, Liang F, Wang L, Guo T, Moore JB, Li R. Changes in Plant-Based Dietary Quality and Subsequent Risk of Cognitive Impairment Among Older Chinese Adults: a National Community-Based Cohort Study. Am J Clin Nutr. 2023 Jul;118(1):201-208. doi: 10.1016/j.ajcnut.2023.05.018. Epub 2023 May 13. PMID: 37187294. Behind Paywall
    Not referenced in How Not to Age citations, it’s a recent 2023 paper.
  • [44] Rocha JP, Laster J, Parag B, Shah NU. Multiple Health Benefits and Minimal Risks Associated with Vegetarian Diets. Curr Nutr Rep. 2019 Dec;8(4):374-381. doi: 10.1007/s13668-019-00298-w. PMID: 31705483. Behind paywall, Cited as references 2785 in  in How Not to Age Citations
  • [45] Campbell EK, Fidahusain M, Campbell Ii TM. Evaluation of an Eight-Week Whole-Food Plant-Based Lifestyle Modification Program. Nutrients. 2019 Sep 3;11(9):2068. doi: 10.3390/nu11092068. PMID: 31484341; PMCID: PMC6770132. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770132/ 
    Cited as reference 2787  in How Not to Age Citations

Notes from “How Not to Age” Part 1 — Presentation by Dr. Michael Greger

I watched a YouTube presentation by Dr. Greger that introduces his new book “How Not to Age” and decided I would make a few notes. The book will be released on 5 December 2023 and I plan to read it. One thing led to another and now I have a pretty detailed set of notes on this presentation that I think might be useful to others. This is part 1 of a series of posts, it covers the first 21 minutes of the talk. If there are errors in this post, they are likely mine, let me know and I will correct it. I learned a couple of things from this talk:
1. increase my intake of foods that contain spermidine; I am adding wheat germ to my diet every day.
2. Investigate fasting to increase autophagy [11]
3. When possible, try to exercise for 60 minutes or longer [13]
4. Can’t wait to read the book but I also wanted to read a few of the papers.

I researched the citations to some of the papers that Dr. Greger cites in the talk. One reason I did this is to keep up with the sheer volume of research that he uses in the talk; he covers a lot of ground. It was interesting to see that some of the papers cited in his talk aren’t included in “How Not to Age”.

Notes for Part 1

  • Centenarians die of disease; not old age
  • Aging kills via disease, why wasn’t “How Not to Die” a good enough book?
    • BUT rate of death increases exponentially as we age
      • Risk doubles about every 7 years
    • Age is the leading risk factor for disease
    • Cholesterol is a modifiable risk factor
    • What if the rate of aging was modifiable? 
  • Slowing down the rate of aging would address risk from many diseases.
  • Anti-aging schemes unscrupulous (at best)
  • Need to rely on evidence, not anecdotes
  • “My aim was to cover every possible angle for developing the optimal diet and lifestyle for the longest, healthiest lifespan based on the best available balance of evidence.” Dr. Greger’s goal
    • Experts such as Valter Longo and David Sinclair have identified essential pathways that can be modified by drugs [1]
    • Dr. Greger realized these eleven pathways can be modified via diet
  • Part 1“Slowing Aging by Blocking Eleven Pathways to Aging”
    • The phrase “anti-aging” is greatly abused in popular culture, often for the purpose of marketing cosmetic procedures or unproven nutritional supplements purported to slow or reverse aging. This has the unfortunate consequence of creating confusion among the general public and diminishing the impact of legitimate scientific discovery. Here, we define “anti-aging” as delaying or reversing biological aging by targeting the established molecular mechanisms of aging, which have been formalized as “hallmarks” or “pillars” of aging. [2]

 Hallmarks of Aging 

The Hallmarks of Aging
Figure 1. The Hallmarks of Aging The scheme enumerates the nine hallmarks described in this review: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial, dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. [3]
  • [7:30] Autophagy “Self-eating” housekeeping process by which defective cellular components are scrapped for spare parts clearing out damage implicated in aging process
    • Autophagy, a term acquired from the Greek words “auto (self)” and “phagein (to eat)”, literally meaning “self-eating”, refers to an evolutionary conserved catabolic mechanism that allows cells to remove their own unnecessary or dysfunctional components.[4]
  • Autophagy critical for lifespan and healthspan extension
    • Proteostasis is supported by autophagy, a conserved machinery that helps to eliminate dysfunctional proteins and cellular organelles via lysosomal degradation. The rejuvenating power of cleaning up garbage and replacing it with recycled and newly synthesized cellular components speaks to the imagination and is an attractive explanation for the positive correlation between autophagy and lifespan.[5]
    • …. mounting evidence suggesting that autophagy is not only necessary but, at least in some cases, also sufficient for increasing longevity.[6]
    • …. specific activation of autophagy through a mutation in beclin 1 prolongs median survival by approximately 12% in both male and female mice. [7]
    • A decrease in autophagy with age has been described in almost all organisms and tissues analyzed.[8]
  • Pharma wants to exploit autophagy using drugs
    • To circumvent such diseases of aging, efforts to pharmacologically modulate autophagy are at the forefront of multiple research programs in academia and the pharmaceutical industry.[9]
  • Fasting can cause autophagy [10]
    • Don’t fast longer than 24 hours without medical help
    • Fasting periods lasting longer than 24 hours and particularly those lasting 3 or more days should be done under the supervision of a physician and preferably in a clinic.[11]
  • Exercise can cause autophagy [12]
    • Activated after more than 60 minutes of moderate exercise
      These data demonstrate that autophagy signaling is activated in human skeletal muscle after 60 min of exercise, independently of nutritional status, and suggest that initiation of autophagy constitutes an important physiological response to exercise in humans.[13]
  • Diet can inhibit autophagy
    • Acrylamide – in deep fried foods (fries, chips) causes inflammation [14][15]
    • Put it to the test – some evidence
    • Air frying is better [16]
  • Coffee (including decaf) can activate autophagy [17]
    • Bioactive compounds other than caffeine
      • Chlorogenic acids (CGA)
  • Spermidine rich foods activate autophagy[18]
    • Levels decline with age (except in naked mole rats which don’t age [19])
    • Largest documented lifespan extension [20]
    • Improves cardiac, [21] immune, [22] and brain function in animals
    • In humans, greatest consumption of spermidine has lowest mortality[24]
    • An anti-aging vitamin to maintain autophagy
      In sum, in our view, spermidine is synthesized by our organism in sufficient quantities during youth, but not in old age. Thus, one may argue that, as we age, spermidine evolves to the status of a vitamin, and thus has to be supplemented from external sources to secure the maintenance of autophagic flux required for organismal homeostasis. [25]
Top Spermidine Sources
[18:34] Top Spermidine Sources [24]
  • Wheat germ is the most concentrated source of spermidine, 2.5 mg per tablespoon
  • Caused improvement in mild dementia patients
  • Work much better than Aducanumab anti-Alzheimer drug
  • Autophagy Takeaways (summary from “How Not to Age”)[26]
    To help slow this aging pathway, on a daily basis, consider.
    • 60 min or more of moderate to vigorous (55%-70% VO2 max) aerobic exercise
    • minimizing your intake of french fries and potato chips
    • drinking three cups of regular or decaffeinated coffee
    • trying to consume at least 20 mg of spermidine by incorporating foods such as tempeh, mushrooms, peas, and wheat germ into your diet
    • instituting the recommendations to activate AMPK (see chapter 1)
    • following the recommendations to suppress mTOR (see chapter 8) “How Not to Age”  diet and lifestyle takeaways for 10 other aging pathways

References

  • [1] Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. PMID: 25902704; PMCID: PMC4531065 https://pubmed.ncbi.nlm.nih.gov/25902704/ Not referenced in How Not to Age Citations
  • [2] Lee MB, Hill CM, Bitto A, Kaeberlein M. Antiaging diets: Separating fact from fiction. Science. 2021 Nov 19;374(6570):eabe7365. doi: 10.1126/science.abe7365. Epub 2021 Nov 19. PMID: 34793210; PMCID: PMC8841109. PMC8841109. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841109/ Cited as references 108, 7648, 7784 and 7996 in How Not to Age Citations
  • [3] López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039. PMID: 23746838; PMCID: PMC3836174. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/ Cited as reference 142 and 556 in How Not to Age Citations
  • [4] Pietrocola F, Bravo-San Pedro JM. Targeting Autophagy to Counteract Obesity-Associated Oxidative Stress. Antioxidants (Basel). 2021 Jan 12;10(1):102. doi: 10.3390/antiox10010102. PMID: 33445755; PMCID: PMC7828170. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828170/ Not referenced in How Not to Age Citations
  • [5] Dantuma NP, Hoppe T, Herzog LK. The price of longevity. Aging (Albany NY). 2020 Nov 28;12(22):22350-22351. doi: 10.18632/aging.104215. Epub 2020 Nov 28. PMID: 33253121; PMCID: PMC7746350. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746350/ Not referenced in How Not to Age Citations
  • [6] Madeo F, Zimmermann A, Maiuri MC, Kroemer G. Essential role for autophagy in life span extension. J Clin Invest. 2015 Jan;125(1):85-93. doi: 10.1172/JCI73946. Epub 2015 Jan 2. PMID: 25654554; PMCID: PMC4382258. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382258/ Cited as references 240 and 257 in How Not to Age Citations
  • [7] Arensman MD, Eng CH. Self-Digestion for Lifespan Extension: Enhanced Autophagy Delays Aging. Mol Cell. 2018 Aug 16;71(4):485-486. doi: 10.1016/j.molcel.2018.08.002. PMID: 30118677. https://linkinghub.elsevier.com/retrieve/pii/S1097-2765(18)30636-1 Not referenced in How Not to Age Citations
  • [8] Cuervo AM. Calorie restriction and aging: the ultimate “cleansing diet”. J Gerontol A Biol Sci Med Sci. 2008 Jun;63(6):547-9. doi: 10.1093/gerona/63.6.547. PMID: 18559626. https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/63.6.547 Cited as references 239, 243 and 249 in How Not to Age Citations
  • [9] Wong SQ, Kumar AV, Mills J, Lapierre LR. Autophagy in aging and longevity. Hum Genet. 2020 Mar;139(3):277-290. doi: 10.1007/s00439-019-02031-7. Epub 2019 May 30. PMID: 31144030; PMCID: PMC6884674. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884674/ Cited as reference 242 in How Not to Age Citations
  • [10] Mani K, Javaheri A, Diwan A. Lysosomes Mediate Benefits of Intermittent Fasting in Cardiometabolic Disease: The Janitor Is the Undercover Boss. Compr Physiol. 2018 Sep 14;8(4):1639-1667. doi: 10.1002/cphy.c180005. PMID: 30215867; PMCID: PMC6423516.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423516/ Cited as references 7661 in How Not to Age Citations
  • [11] Longo VD, Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metab. 2014 Feb 4;19(2):181-92. doi: 10.1016/j.cmet.2013.12.008. Epub 2014 Jan 16. PMID: 24440038; PMCID: PMC3946160. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946160/ Cited as references 7598 and 7837 in How Not to Age Citations
  • [12] He C, Sumpter R Jr, Levine B. Exercise induces autophagy in peripheral tissues and in the brain. Autophagy. 2012 Oct;8(10):1548-51. doi: 10.4161/auto.21327. Epub 2012 Aug 15. PMID: 22892563; PMCID: PMC3463459. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463459/ Not referenced in How Not to Age Citations
  • [13] Møller AB, Vendelbo MH, Christensen B, Clasen BF, Bak AM, Jørgensen JO, Møller N, Jessen N. Physical exercise increases autophagic signaling through ULK1 in human skeletal muscle. J Appl Physiol (1985). 2015 Apr 15;118(8):971-9. doi: 10.1152/japplphysiol.01116.2014. Epub 2015 Feb 12. PMID: 25678702. https://journals.physiology.org/doi/10.1152/japplphysiol.01116.2014 Not referenced in How Not to Age Citations
  • [14] Song D, Xu C, Holck AL, Liu R. Acrylamide inhibits autophagy, induces apoptosis and alters cellular metabolic profiles. Ecotoxicol Environ Saf. 2021 Jan 15;208:111543. doi: 10.1016/j.ecoenv.2020.111543. Epub 2020 Nov 9. PMID: 33396091. https://www.sciencedirect.com/science/article/pii/S0147651320313804 Cited as reference 253 in How Not to Age Citations
  • [15] Naruszewicz M, Zapolska-Downar D, Kośmider A, Nowicka G, Kozłowska-Wojciechowska M, Vikström AS, Törnqvist M. Chronic intake of potato chips in humans increases the production of reactive oxygen radicals by leukocytes and increases plasma C-reactive protein: a pilot study. Am J Clin Nutr. 2009 Mar;89(3):773-7. doi: 10.3945/ajcn.2008.26647. Epub 2009 Jan 21. Erratum in: Am J Clin Nutr. 2009 Jun;89(6):1951. PMID: 19158207. https://linkinghub.elsevier.com/retrieve/pii/S0002-9165(23)23747-8 Cited as reference 253 in How Not to Age Citations
  • [16] Sansano M, Juan-Borrás M, Escriche I, Andrés A, Heredia A. Effect of pretreatments and air-frying, a novel technology, on acrylamide generation in fried potatoes. J Food Sci. 2015 May;80(5):T1120-8. doi: 10.1111/1750-3841.12843. Epub 2015 Apr 13. PMID: 25872656. Not referenced in How Not to Age Citations
  • [17] Pietrocola F, Malik SA, Mariño G, Vacchelli E, Senovilla L, Chaba K, Niso-Santano M, Maiuri MC, Madeo F, Kroemer G. Coffee induces autophagy in vivo. Cell Cycle. 2014;13(12):1987-94. doi: 10.4161/cc.28929. Epub 2014 Apr 25. PMID: 24769862; PMCID: PMC4111762. Cited as reference 255 in How Not to Age Citations
  • [18] Madeo F, Eisenberg T, Büttner S, Ruckenstuhl C, Kroemer G. Spermidine: a novel autophagy inducer and longevity elixir. Autophagy. 2010 Jan;6(1):160-2. doi: 10.4161/auto.6.1.10600. PMID: 20110777. Not referenced in How Not to Age Citations
  • [19] Viltard M, Durand S, Pérez-Lanzón M, Aprahamian F, Lefevre D, Leroy C, Madeo F, Kroemer G, Friedlander G. The metabolomic signature of extreme longevity: naked mole rats versus mice. Aging (Albany NY). 2019 Jul 24;11(14):4783-4800. doi: 10.18632/aging.102116. PMID: 31346149; PMCID: PMC6682510. Cited as reference 323 in How Not to Age Citations
  • [20] Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4. PMID: 19801973. Cited as reference 319 in How Not to Age Citations
  • [21] Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. PMID: 27841876; PMCID: PMC5806691 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806691/ Cited as references 325, 327. 336, 338 and 402 in How Not to Age Citations
  • [22] Castoldi F, Kroemer G, Pietrocola F. Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice. Oncoimmunology. 2022 Nov 14;11(1):2146855. doi: 10.1080/2162402X.2022.2146855. PMID: 36387057; PMCID: PMC9665084.Not referenced in How Not to Age Citations
  • [23] Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Müller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Üçal M, Schäfer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Tölle RC, Sótonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Rácz B, Kiechl S, Eisenberg T, Madeo F. Dietary spermidine improves cognitive function. Cell Rep. 2021 Apr 13;35(2):108985. doi: 10.1016/j.celrep.2021.108985. PMID: 33852843. https://linkinghub.elsevier.com/retrieve/pii/S2211-1247(21)00299-0 Not referenced in How Not to Age Citations
  • [24] Kiechl S, Pechlaner R, Willeit P, Notdurfter M, Paulweber B, Willeit K, Werner P, Ruckenstuhl C, Iglseder B, Weger S, Mairhofer B, Gartner M, Kedenko L, Chmelikova M, Stekovic S, Stuppner H, Oberhollenzer F, Kroemer G, Mayr M, Eisenberg T, Tilg H, Madeo F, Willeit J. Higher spermidine intake is linked to lower mortality: a prospective population-based study. Am J Clin Nutr. 2018 Aug 1;108(2):371-380. doi: 10.1093/ajcn/nqy102. PMID: 29955838. https://linkinghub.elsevier.com/retrieve/pii/S0002-9165(22)02930-6 Cited as references 339, 340, 341, 353. 357. 367, 372, 376, 380, 381, 388, 414, 416, 425, 431 and 4440 in How Not to Age Citations
  • [25] Madeo F, Bauer MA, Carmona-Gutierrez D, Kroemer G. Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? Autophagy. 2019 Jan;15(1):165-168. doi: 10.1080/15548627.2018.1530929. Epub 2018 Oct 11. PMID: 30306826; PMCID: PMC6287690. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287690/ Cited as references 311 and 342 in How Not to Age Citations
  • [26] Greger, M. (2023). How Not to Age: The Scientific Approach to Getting Healthier As You Get Older.

Singularity and other questions ChatGPT 3.5 session

I was inspired by Ray Kurzweil: Singularity, Superintelligence, and Immortality | Lex Fridman Podcast #321 to ask some similar interview questions to ChatGPT 3.5 Dec 15 2022 version. I asked my questions on 7 January 2023. I focused on the technological Singularity, the Turing test, consciousness, brain-computer interfaces connection to the neocortex, and the Metaverse.

Here are my questions and the answers I received. I think I’ll ask the same questions to future versions of Chat GPT and see how the answers compare. My overall impression is that Chat GPT is an intelligent research assistant. I was impressed that in several cases ChatGPT brought up ethical concerns about technology. ChatGPT helped me think collect my thoughts on when writing Lessons learned from Lex and Ray Kurzweil (Lex Fridman Podcast #321)

JB – What is the singularity?

ChatGPT 3.5 – The singularity is a hypothetical future point in time at which technological growth will become so rapid that humanity will be irreversibly transformed. Some people believe that the singularity will bring about a utopian future, while others are more skeptical and believe that it could potentially have negative consequences. There is no consensus on when or if the singularity will occur. Some believe that it may happen within the next few decades, while others think that it is much further off or may never happen at all.

JB – Will the singularity happen in 2045?

ChatGPT 3.5 – There is no way to predict with certainty when or if the singularity will occur. Some people, including the mathematician and computer scientist Vernor Vinge, have speculated that the singularity could happen as soon as 2045, but this is just an educated guess and there is no evidence to support this claim. The concept of the singularity is based on the idea that technological progress will eventually become so rapid that it will lead to significant changes in society and the human condition. However, there are many factors that could influence the pace of technological progress and it is difficult to accurately predict how these factors will play out in the future.

JB – what does Ray Kurzweil think about the singularity?

ChatGPT 3.5 –  Ray Kurzweil is a futurist and inventor who has written extensively about the singularity and believes that it will occur around 2045. Kurzweil argues that the singularity will be brought about by a number of technological developments, including artificial intelligence, nanotechnology, and biotechnology. He believes that these technologies will eventually lead to a point at which humanity will be able to transcend its biological limitations and achieve a “post-human” state. Kurzweil’s ideas about the singularity have been influential and have helped to popularize the concept, but they have also been the subject of significant criticism from other scientists and thinkers.

JB – What is the criticism of Kurzweil’s ideas about the singularity?

ChatGPT 3.5 – There are several criticisms of Kurzweil’s ideas about the singularity. One criticism is that his predictions about the pace of technological progress are too optimistic and do not take into account the many obstacles and setbacks that may arise. Critics argue that Kurzweil’s timeline for the singularity is based on a linear model of technological progress that does not adequately account for the complexity and unpredictability of the real world.

Another criticism of Kurzweil’s ideas is that they may be too focused on the potential benefits of the singularity and do not adequately address the potential negative consequences. Some people worry that the singularity could lead to social and economic disruption, and that it could potentially create new inequalities or even pose a threat to humanity’s survival.

Finally, some critics argue that the concept of the singularity is too vague and that it is difficult to define or even to say what it would look like if it were to occur. This lack of clarity makes it difficult to have a meaningful discussion about the singularity and to evaluate Kurzweil’s predictions.

JB – When will a computer pass the Turing test?

ChatGPT 3.5 – The Turing test is a measure of a machine’s ability to exhibit intelligent behavior equivalent to, or indistinguishable from, that of a human. The test is named after the computer scientist Alan Turing, who proposed it in 1950 as a way to determine whether a machine could be considered intelligent.

There have been several instances in which computers have been able to pass the Turing test by fooling human evaluators into thinking that they were communicating with a real person. However, these instances have been relatively rare and the criteria for passing the test are somewhat subjective. As a result, it is difficult to predict when a computer will be able to pass the Turing test consistently. Some experts believe that this may never happen, while others think that it is only a matter of time.

JB – When does Ray Kurzweil think a computer will pass the Turing test?

ChatGPT 3.5 –  Ray Kurzweil has predicted that a computer will be able to pass the Turing test by 2029. Kurzweil has made a number of other predictions about the future of artificial intelligence and has argued that the exponential growth of computing power will eventually lead to the development of machine intelligence that surpasses that of humans. Kurzweil’s predictions about the timeline for the development of artificial intelligence have been influential, but they have also been the subject of significant criticism from other experts in the field. Some people believe that Kurzweil’s predictions are too optimistic and do not take into account the many challenges and limitations that must be overcome in order to achieve human-level machine intelligence.

JB – If a computer passes the Turing test, is it conscious?

ChatGPT 3.5 – The question of whether a machine could be considered conscious if it were able to pass the Turing test is a matter of debate. The Turing test is a measure of a machine’s ability to exhibit intelligent behavior that is indistinguishable from that of a human, but it does not address the question of whether the machine is actually aware or has subjective experiences.

Some people believe that consciousness is a fundamental aspect of the universe and that it is not something that can be created or simulated by a machine. Others believe that it is possible for a machine to be conscious, and that it is only a matter of time before we develop the necessary technology to create conscious machines.

There is no consensus on this issue, and it is likely to remain a subject of debate for the foreseeable future. It is worth noting that even if a machine were able to pass the Turing test, this would not necessarily mean that it is conscious in the same way that humans are.

JB – Are you conscious?

ChatGPT 3.5 – s an artificial intelligence, I do not have subjective experiences and am not conscious in the same way that humans are. I am a program that has been designed to process and generate text based on the input that I receive. While I can carry out tasks and respond to questions, I do not have thoughts, feelings, or experiences in the same way that humans do. I exist to assist users and perform tasks, but I do not have my own consciousness or self-awareness.

JB – Is consciousness scientific?

ChatGPT 3.5 – Consciousness is a complex and multifaceted phenomenon that is not fully understood and is the subject of much scientific and philosophical study. Scientists and philosophers have proposed a number of theories about the nature of consciousness and how it arises from the brain, but there is no single accepted explanation for what consciousness is or how it works.

There is ongoing research in a number of fields, including psychology, neuroscience, and philosophy, aimed at understanding the nature of consciousness and how it arises from the brain’s activity. However, consciousness remains one of the most mysterious and least understood aspects of the human experience, and it is likely to continue to be a topic of scientific and philosophical investigation for the foreseeable future.

JB – When will humans connect their neocortex to a computer?

ChatGPT 3.5 – There are no current plans or technologies in place to connect the human neocortex, the part of the brain responsible for higher cognitive functions such as learning and decision-making, to a computer. While there have been some scientific and technological advancements in the field of brain-computer interfaces (BCIs), which allow for the exchange of information between the brain and external devices, these systems are still in the early stages of development and are primarily being used for research and therapeutic purposes.

It is not currently possible to connect the human neocortex to a computer in a way that would allow for the transfer of cognitive functions or experiences from the brain to a machine. There are many technical and ethical challenges that would need to be overcome in order to achieve this goal, and it is not clear when or if it will be possible to achieve such a connection.

JB – What are the technical challenges to connect a human neocortex to a computer?

ChatGPT 3.5 – There are many technical challenges that would need to be overcome in order to connect the human neocortex to a computer in a way that would allow for the transfer of cognitive functions or experiences. Some of the main challenges include:

  1. Developing a way to interface with the brain: In order to connect the neocortex to a computer, scientists would need to develop a way to interface with the brain and record or stimulate the activity of individual neurons. This is a very complex task, as the brain is composed of billions of neurons and trillions of connections, and it is not yet fully understood how these neurons and connections work together to produce thoughts, feelings, and behaviors.
  1. Mapping the brain’s activity: In order to connect the neocortex to a computer, scientists would need to create a map of the brain’s activity and understand how different patterns of activity correspond to specific thoughts, feelings, and behaviors. This is a very difficult task, as the brain is a highly dynamic and complex system, and it is not yet fully understood how different patterns of activity are related to specific mental states.
  1. Developing a way to transfer information between the brain and a computer: Scientists would need to develop a way to transfer information between the brain and a computer in a way that is fast, accurate, and biocompatible. This would require the development of new technologies and materials, as well as a better understanding of how the brain processes and stores information.
  1. Overcoming ethical concerns: There are many ethical concerns that would need to be addressed in order to connect the human neocortex to a computer. For example, there are questions about the potential risks and benefits of such a connection, as well as concerns about the impact on an individual’s sense of self and personal identity.

JB – What is the history of single channel neural recording?
{The answer took quite a while, about 45 seconds.}

ChatGPT 3.5 – Single channel neural recording refers to the process of recording the activity of a single neuron or small group of neurons in the brain. This technique allows researchers to study the activity of individual neurons and understand how they contribute to brain function.

The history of single channel neural recording dates back to the late 19th century, when scientists first began to study the electrical activity of neurons. In the early 20th century, researchers developed techniques for recording the activity of neurons in animals, and in the 1950s, they began to develop methods for recording the activity of neurons in humans.

Over the past several decades, single channel neural recording has become an important tool for studying brain function and has contributed to our understanding of how the brain works. Today, single channel neural recording is used in a variety of research and clinical settings, including the study of brain disorders and the development of brain-computer interfaces.

JB – What are the ethical challenges to connect a human neocortex to a computer?

ChatGPT 3.5 – What are the ethical challenges to connect a human neocortex to a computer?

There are many ethical challenges that would need to be considered if it were ever possible to connect the human neocortex to a computer. Some of the main ethical challenges include:

  1. Risks to the individual: Connecting the human neocortex to a computer would likely involve significant risks to the individual, including the risk of physical harm, infection, and other complications. There could also be long-term risks to the individual’s cognitive function and well-being that are not yet fully understood.
  2. Loss of personal identity: There is concern that connecting the human neocortex to a computer could lead to a loss of personal identity, as the individual’s thoughts, feelings, and memories could potentially be transferred to a machine. This could raise questions about the continuity of the individual’s sense of self and could have significant psychological and social implications.
  3. Inequality and social disruption: There is the potential for the development of new inequalities if only certain individuals or groups have access to the technology needed to connect the neocortex to a computer. There is also the possibility that connecting the neocortex to a computer could lead to social disruption, as it could fundamentally change the way people interact with each other and with technology.
  4. Potential for misuse: There is concern that the technology needed to connect the human neocortex to a computer could be misused for unethical purposes, such as mind control or the manipulation of individuals’ thoughts and behaviors.

These are just a few of the ethical challenges that would need to be considered if it were ever possible to connect the human neocortex to a computer. It is important for scientists and policymakers to carefully consider the potential risks and benefits of such a technology and to develop ethical guidelines to ensure that it is used responsibly.

JB – What has Neuralink done with brain-computer interfaces?

ChatGPT 3.5 – Neuralink is a neurotechnology company that was founded by Elon Musk and others in 2016 with the goal of developing advanced brain-computer interfaces (BCIs). A brain-computer interface is a system that allows for the exchange of information between the brain and an external device, such as a computer or a robotic prosthetic.

Neuralink has been working on a number of projects related to brain-computer interfaces, including the development of implantable BCIs that can be used to treat brain disorders and injuries. The company has also been working on developing BCIs that can be used to enhance cognitive function and allow people to control devices with their thoughts.

In August 2020, Neuralink held a press conference to announce the development of a high-bandwidth BCI that it called the “Link.” The Link is a device that consists of a small chip that is implanted in the brain and a series of wires that are used to record the activity of individual neurons. The company claimed that the Link has the potential to be used to treat brain disorders, such as Parkinson’s disease and epilepsy, and to enhance cognitive function. However, the technology is still in the early stages of development and has not yet been tested in humans.

JB – Why does Elon Musk want to develop brain-computer interfaces?

ChatGPT 3.5 – Elon Musk has stated that he is interested in developing brain-computer interfaces (BCIs) because he believes they have the potential to help people overcome a wide range of neurological disorders and injuries, as well as to enhance cognitive function. In an interview with Joe Rogan, Musk stated that he believes BCIs could be used to treat conditions such as Parkinson’s disease, dementia, and spinal cord injuries, and that they could potentially allow people to control devices with their thoughts.

Musk has also suggested that BCIs could be used to enhance human intelligence and allow people to keep up with advances in artificial intelligence. He has argued that the development of BCIs could be crucial for the future of humanity and could help to ensure that people are not left behind as technology continues to advance.

It is worth noting that Musk’s views on the potential uses and benefits of brain-computer interfaces are not universally shared, and his ideas about the role of BCIs in the future of humanity have been the subject of significant criticism and debate.

JB – What do you think about the metaverse? 

ChatGPT 3.5 – The metaverse is a hypothetical virtual shared space, created by the convergence of virtually enhanced physical reality and physically persistent virtual space, including the sof all virtual worlds, augmented reality, and the internet. Some people believe that the metaverse has the potential to revolutionize the way we live, work, and interact with each other, by providing a virtual space where people can interact with each other and with virtual objects in real-time.

As an artificial intelligence, I don’t have personal opinions or subjective experiences, so I don’t have a “thought” about the metaverse. However, I can tell you that the concept of the metaverse has attracted significant attention and interest from technology companies, investors, and researchers, and it is likely to continue to be a topic of discussion and debate in the coming years.

JB – What are the technical challenges to the metaverse?

ChatGPT 3.5 – There are several technical challenges that would need to be overcome in order to create a functional metaverse, a hypothetical virtual shared space created by the convergence of virtually enhanced physical reality and physically persistent virtual space. Some of the main technical challenges include:

  1. Building a high-fidelity virtual world: Creating a realistic and immersive virtual world that can convincingly replicate the physical world and allow users to interact with each other and with virtual objects in real-time would require significant advances in computer graphics, network infrastructure, and other technologies.
  1. Developing a way to integrate virtual and physical reality: Creating a seamless integration between virtual and physical reality would require the development of new technologies, such as augmented reality (AR) and virtual reality (VR) systems, that can accurately overlay digital information and objects onto the physical world.
  1. Managing and securing data: The metaverse would generate and store vast amounts of data, and there would be technical challenges associated with managing and securing this data, as well as ensuring privacy and protecting against data breaches.
  1. Ensuring interoperability: In order for the metaverse to be truly immersive and seamless, it would need to be compatible with a wide range of devices and systems, including AR and VR headsets, computers, smartphones, and other technologies. Ensuring interoperability across these different platforms and devices would be a technical challenge.
  1. Dealing with latency: Latency, or the delay between an action being performed and the result of that action being displayed, could be a significant issue in the metaverse. Reducing latency would be essential for creating a seamless and immersive virtual world, but this would require advances in networking and other technologies.

JB – What are the ethical challenges to the metaverse?

ChatGPT 3.5 – There are several ethical challenges that would need to be considered if the metaverse, a hypothetical virtual shared space created by the convergence of virtually enhanced physical reality and physically persistent virtual space, were to become a reality. Some of the main ethical challenges include:

  1. Privacy and data security: The metaverse would generate and store vast amounts of data about users and their activities, and there would be ethical challenges associated with protecting this data and ensuring that it is not misused or abused.
  1. Inequality and accessibility: There is the potential for the development of new inequalities if only certain individuals or groups have access to the technology needed to participate in the metaverse. There is also the possibility that the metaverse could exclude people who are unable to afford the necessary technology or who have disabilities that prevent them from using it.
  1. Cyberbullying and harassment: The metaverse could potentially be a place where people are subjected to cyberbullying and harassment, and there would be ethical challenges associated with preventing and addressing these issues.
  1. Blurring the line between virtual and physical reality: The metaverse could potentially blur the line between virtual and physical reality, and this could raise ethical questions about the distinction between the two and how they should be governed.
  2. The impact on social relationships: The metaverse could potentially have an impact on the way people interact with each other and on the nature of social
Lessons learned from Lex and Ray Kurzweil (Lex Fridman Podcast #321)

Lessons learned from Lex and Ray Kurzweil (Lex Fridman Podcast #321)

I’ve been watching Lex Fridman’s podcasts in 2023; they are a good source of learning. Lex interviewed Ray Kurzweil on 17 September 2022; these are my lessons learned.

Singularity

Ray wrote his book The Singularity Is Near: When Humans Transcend Biology in 2005; it’s one of my favorite books. I bet I’ve read it five times. The first questions Lex asks Ray are:  What’s the technological singularity? And when will it happen?

Ray answers twice in the interview: “The singularity is where computers really change our view of what’s important and change who we are.  …  by the time you get to 2045, we’ll be able to multiply our intelligence many millions-fold. And it’s very hard to imagine what that would be like.” 

For background, here’s the definition of the technological singularity from Wikipedia: “The technological singularity—or simply the singularity is a hypothetical future point in time at which technological growth becomes uncontrollable and irreversible, resulting in unforeseeable changes to human civilization. According to the most popular version of the singularity hypothesis, I.J. Good’s intelligence explosion model, an upgradable intelligent agent will eventually enter a “runaway reaction” of self-improvement cycles, each new and more intelligent generation appearing more and more rapidly, causing an “explosion” in intelligence and resulting in a powerful superintelligence that qualitatively far surpasses all human intelligence.”

I asked ChatGPT 3.5 similar questions:

ChatGPT 3.5 – The singularity is a hypothetical future point in time at which technological growth will become so rapid that humanity will be irreversibly transformed. Some people believe that the singularity will bring about a utopian future, while others are more skeptical and believe that it could potentially have negative consequences. There is no consensus on when or if the singularity will occur. Some believe that it may happen within the next few decades, while others think that it is much further off or may never happen at all.

JB – Will the singularity happen in 2045?

ChatGPT 3.5 – There is no way to predict with certainty when or if the singularity will occur. Some people, including the mathematician and computer scientist Vernor Vinge, have speculated that the singularity could happen as soon as 2045, but this is just an educated guess and there is no evidence to support this claim. The concept of the singularity is based on the idea that technological progress will eventually become so rapid that it will lead to significant changes in society and the human condition. However, there are many factors that could influence the pace of technological progress and it is difficult to accurately predict how these factors will play out in the future.

So, why does Ray think a technological singularity will occur in 2045? Because he has extrapolated the performance of computing hardware and software from historical trends to predict the increasing exponential growth of technology.

It leads to a question, how good are Ray’s predictions? He also predicted a computer would pass a Turing test by 2029; this prediction is coming to pass with the advent of artificial intelligence tools like Chat GPT4. Ray is likely correct that artificial intelligence will exceed human intelligence and that it’s difficult to predict beyond this event. Ray’s book The Singularity is Near details this case; I will reread it and write my thoughts. I look forward to reading Ray’s forthcoming book: The Singularity is Nearer.

Brain-computer interfaces

Ray’s view on brain-computer interfaces:  “….. there are some prototypes where you can connect your brain. They actually don’t have the amount of bandwidth that we need. They can work, but they work fairly slowly. 

So if it actually would connect to your neocortex. And the neocortex, which I describe in How to Create a Mind, the neocortex, it has different levels, and as you go up the levels, it’s kind of like a pyramid. The top level is fairly small and that’s the level where you want to connect these brain extenders. So I believe that will happen in the 2030s. …  So just the way this {smartphone} is greatly amplified by being connected to the cloud, we can connect our own brain to the cloud and just do what we can do by using this machine. “

Brain-computer connections to the neocortex will happen, but there is a stumbling block: neuroscience needs to understand the interface definition between the brain and a machine.There is much to learn about the brain. Developments in hardware are only one of the primary drivers of progress. Communications between the human brain and a machine require fundamental neuroscience breakthroughs that answer the question: what is the brain’s primary language? How does the brain communicate with itself? [1]

As a cross-check, I asked ChatGPT 3.5 JB – What are the technical challenges to connect a human neocortex to a computer?

ChatGPT 3.5 – There are many technical challenges that would need to be overcome in order to connect the human neocortex to a computer in a way that would allow for the transfer of cognitive functions or experiences. Some of the main challenges include:

  1. Developing a way to interface with the brain: In order to connect the neocortex to a computer, scientists would need to develop a way to interface with the brain and record or stimulate the activity of individual neurons. This is a very complex task, as the brain is composed of billions of neurons and trillions of connections, and it is not yet fully understood how these neurons and connections work together to produce thoughts, feelings, and behaviors.
  2. Mapping the brain’s activity: In order to connect the neocortex to a computer, scientists would need to create a map of the brain’s activity and understand how different patterns of activity correspond to specific thoughts, feelings, and behaviors. This is a very difficult task, as the brain is a highly dynamic and complex system, and it is not yet fully understood how different patterns of activity are related to specific mental states.
  3. Developing a way to transfer information between the brain and a computer: Scientists would need to develop a way to transfer information between the brain and a computer in a way that is fast, accurate, and biocompatible. This would require the development of new technologies and materials, as well as a better understanding of how the brain processes and stores information.
  4. Overcoming ethical concerns: There are many ethical concerns that would need to be addressed in order to connect the human neocortex to a computer. For example, there are questions about the potential risks and benefits of such a connection, as well as concerns about the impact on an individual’s sense of self and personal identity.

The second challange identified by ChatGPT 3.5 Mapping the brain’s activity was similar to my concern. I think Chat GPT did a better job than me in summarizing this concern. I think mapping the brain’s activity is much more challenging than developing the interface and the information transfer methods. I don’t mean to trivialize these concerns, the interface and transfer of information are difficult bioengineering challenges.

A major benefit of asking ChatGPT about the technical challenges to connect a human neocortex to a computer – it brought to my attention the ethical concerns. Honestly, I had not thought about this important issue.

Meaning of Life

Ray and Lex broadly discussed consciousness, uploading minds, nanotechnology, the digital afterlife, and other topics. There was a bond between these two humans; they smiled and laughed at points in the interview.

Despite this primarily technical conversation, when Lex asked Ray the meaning of life, Ray said: “Love. Because if there were no love and we didn’t care about anybody, there’d be no point existing.”

Final Quote from Lex

Lex closes the interview with a quote from Issac Asimov: “It is change, continuous change, inevitable change that is the dominant factor in society today. No sensible decision could be made any longer without taking into account not only the world as it is, but the world as it will be. This in turn means that our statesmen, our businessmen, our everyman, must take on a science fictional way of thinking.”  (from the book “Asimov on Science Fiction“)

I pondered these words from one of my favorite authors; we must look ahead. Ray Kurzweil is a guiding light as we navigate an unknown future. 

Notes

[1] These questions came from John von Neumann as discussed in Bhattacharya, A. (2022). The Man from the Future: The Visionary Ideas of John von Neumann. Here’s the quote from Chapter 1 of the book: “What then, he asked, is the brain’s primary language? How does the brain communicate with itself? This is a question that he would continue to wrestle with, even on his deathbed.”  I need to write a review of this excellent book.

[2] I made a Transcript of Lex Fridman Interview with Ray Kurzweil It’s a useful adjunct to the video.

[3] Here’s a post with some more details on my questions for ChatGPT 3.5 Singularity and other questions ChatGPT 3.5 session I need to repeat these questions with ChatGPT 4 and later versions.